CAS No.130308-48-4

Chemical Name:HOE 140

SynonymsS-0765;H0E-140;HOE I40;HOE 140;JE-049);Etibant;Icatibant;HOE 140 TFA;Icatibant [inn];HOE 140 USP/EP/BP

CBNumber:CB1318492

Molecular Formula:C59H89N19O13S

Molecular Weight:1304.52

Density 1.60±0.1 g/cm3(Predicted)

storage temp. Sealed in dry,2-8°C

solubility Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)

form powder

pka 3.60±0.21(Predicted)

color white

Description

Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].

Uses

Antagonist (bradykinin).